Have you ever tried to lighten your pores and skin with over-the-counter lightening brokers like hydroquinone however grew exasperated with ready? Are you questioning what your choices for eradicating age spots and pimples scars can be if and when the Meals and Drug Administration takes hydroquinone off the cabinets? In that case, you could wish to find out about one other pores and skin whitener referred to as mequinol (4-hydroxyanisole).
Regardless that the FDA authorised the mixture of mequinol and tretinoin to deal with photo voltaic lentigines (“age spots” or “liver spots”) again in December of 1999, it has taken nearly seven years for this drug to show its effectiveness at treating ethnic pores and skin varieties.
Analysis performed by dermatologist Zoe Draelos has established mequinol and tretinoin as an efficient therapy for lightening age spots or solar spots in Asian, Latin/Hispanic, and African American ethnic teams.
The research concerned 259 topics and in response to report within the Journal of Beauty Dermatology, the vast majority of topics skilled medical stage enhancements of their pores and skin discolorations 4 weeks after beginning the mequinol therapy.
Along with treating age spots, Dr. Susan Taylor of Columbia College, New York has instructed Pores and skin and Allergy Information that docs ought to take into account mixture mequinol and tretinoin remedy for treating publish inflammatory hyperpigmentation (PIH). Taylor explains that PIH happens in areas of the pores and skin that turn out to be infected from a pores and skin harm, a beauty or surgical process or from pimples lesions.
Mequinol security testing
Whereas mequinol might quickly displace hydroquinone as a trusted pores and skin lightener, the query stays, “How protected is mequinol for human use?” Mequinol is definitely a hydroquinone spinoff, which makes one marvel about its potential toxicity.
Nevertheless, members of the American Chemistry Council have administered oral dosages of mequinol to lab rats and rabbits. The animals didn’t die after publicity. Such experiments make mequinol appear non-threatening. Nevertheless, the FDA doesn’t suggest mixture mequinol and tretinoin for pregnant ladies. Plus, ladies who’re capable of turn out to be pregnant ought to take efficient contraception measures when utilizing this pigment correcting therapy.
Potential uncomfortable side effects mequinol embody redness, stinging, burning, irritation, peeling and itching. Furthermore, you have to to train warning when utilizing mequinol in the event you do facial waxing or use astringents that dry the pores and skin. And, you possibly can’t overlook to make use of a sunscreen when utilizing any pores and skin lightening agent.
In the US, the two.0% mequinol and 0.01% tretinoin pores and skin whitening therapy is offered beneath the trademark identify Solage. Whereas mequinol might quickly supplant hydroquinone as a pores and skin lightener, you’ll nonetheless have to go to your physician to get a prescription to be able to profit from this drug.
Sources:
American Chemistry Council Hydroquinone Precursors and Derivatives Panel Hydroquinone Monomethyl Ether Activity Drive. Excessive Productive Quantity (HPV) Problem Program Hydroquinone Monomethyl Ether Class Check Plan 4-Hydroxyanisole. December 20, 2002.
Meals and Drug Administration. Solage Shopper Info. http: //www.fda.gov/cder/consumerinfo/druginfo/solage.htm, January 6, 2006.
Draelos, Zoe Diana. The mixture of two% 4-hydroxyanisole (mequinol) and 0.01% tretinoin successfully improves the looks of photo voltaic lentigines in ethnic teams. Journal of Beauty Dermatology; September 2006, vol 5, no 3, pp. 239-244.
Muirhead, Greg. Combo Remedy Could Be Hydroquinone Various.
Pores and skin & Allergy Information; April 2007, vol 38, no 4, pp 1,34.
